| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
A reassessment of the role of serotonergic system in the control of feeding behavior
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| Autores: |
Medeiros,Magda A.
Costa-e-Sousa,Ricardo H.
Olivares,Emerson L.
Côrtes,Wellington S.
Reis,Luís C.
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| Data: |
2005-03-01
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| Ano: |
2005
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| Palavras-chave: |
Food ingestion
Serotonergic system
Dorsal raphe nucleus
Electrolytic lesion
Para-chlorophenylalanine
Obesity
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| Resumo: |
The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In the acute study, the LHTP reverted partially the PCPA-induced increase in food intake of fasted rats suggesting a sustained capacity of decarboxylation of precursor by serotonergic neurons. Slow restoration of the levels of food intake in DRN-lesioned rats reveals a neuroplasticity in the systems that regulate feeding behavior. A plateau on the body weight curve in lesioned rats possibly represents the establishment of a new and higher set point of energetic balance.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652005000100008
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.77 n.1 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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